The Estonian Blood Transfusion Service consists of four separated blood centers merged to the big hospitals: North Estonia Medical Center’s Blood Center located in capital city of Tallinn, Tartu University Hospital Blood Center, Pärnu Hospital Blood Center and East-Viru Central Hospital Blood Center. All together they collected 51.349 donations in 2021: 27.180 in Tallinn, 15.439 in Tartu, 5.280 in Pärnu and 3.450 in East-Viru. Estonia has 1,33 million inhabitants. 2,6% of the population is donating blood. Blood components are used in 24 hospitals in Estonia, most of them (21) are supplied by Tallinn’s and Tartu’s Blood Centers. The Blood Transfusion Service action is regulated by the Blood Act and its bylaws (since May 2005). The Estonian Blood Act is in accordance with related European Directives.